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presystemic metabolism

1 пресистемный метаболизм

1) Medicine: first-pass metabolism, presystemic metabolism, first-pass degradation

2) Pharmacology: first-pass effect (после перорального употребления инактивация лекарственных веществ в печени до попадания в системный кровоток)

Универсальный русско-английский словарь > пресистемный метаболизм
2 пресистемный метаболизм

first-pass [presystemic] metabolism

Большой русско-английский медицинский словарь > пресистемный метаболизм

List of drugs affected by grapefruit — Grapefruit and grapefruit juice has the potential to interact with numerous drugs. A number of organic compounds with the most potent that were identified as furanocoumarin derivates interfere with the intestinal enzyme cytochrome P450 isoform… … Wikipedia
First pass effect — The first pass effect (also known as first pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.After a drug is swallowed,… … Wikipedia
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Sumatriptan — drugbox IUPAC name = 1 [3 (2 dimethylaminoethyl) 1H indol 5 yl] N methyl methanesulfonamide CAS number = 103628 46 2 ATC prefix = N02 ATC suffix = CC01 ATC supplemental = PubChem = 5358 DrugBank = APRD00379 C = 14 |H = 21 |N = 3 |O = 2 |S = 1… … Wikipedia
Methadon — Strukturformel Struktur ohne Stereochemie Allgemeines … Deutsch Wikipedia